1035 - The relationship of body mass index on patient reported outcomes after platelet-rich plasma versus microfragmented adipose tissue for knee osteoarthritis

Objectives: The purpose of this investigation is to analyze the previously unstudied effect of body mass index (BMI) on patient reported outcomes (PROs) for patients with knee OA receiving either platelet rich plasma (PRP) or microfragmented adipose tissue (MFAT). We hypothesized that BMI would be negatively correlated with PROs for PRP and MFAT.

Design: This study is a secondary analysis of a randomized, unblinded study comparing PRP versus MFAT for unilateral knee OA, aiming to evaluate the association of BMI with PRO for each group. Of the 79 patients who were screened in the sports medicine clinic, a total of 71 were randomized, and 49 patients completed the 12 month follow-up. For the secondary analysis, patient demographics were collected, and the Knee Osteoarthritis and injury Outcome Score (KOOS) subscales at 12-months after treatment were analyzed.

Results: At the conclusion of the study, KOOS Quality of life and ADL subscores at 1-year was inversely correlated (p < 0.05) with baseline BMI in the MFAT but not the PRP group. KOOS Pain and Sport subscores tended (p < 0.10) to inversely correlate with BMI in the MFAT but not the PRP group. Patient reported outcomes were not associated with BMI in the PRP group. The only difference in demographics was that more women were allocated to MFAT and more men to PRP (p < 0.05).

Conclusions: This investigation demonstrated an inverse association between baseline BMI and patient reported outcomes at 1-year in the MFAT group but not in the PRP group. This suggests that a lower BMI at the time of treatment is associated with improved patient reported outcomes 1-year after treatment. Based on these results, future studies with larger samples would help confirm and identify BMI cutoffs that would be associated with better outcomes after treatment with MFAT.